"Besides replicating very quickly, the 1918 strain seems to trigger a particularly intense response from the immune system, including a ‘cytokine storm’ – the rapid release of immune cells and inflammatory molecules.
Although a robust immune response should help us fight infection, an over-reaction of this kind can overload the body, leading to severe inflammation and a build-up of fluid in the lungs that could increase the chance of secondary infections.
The cytokine storm might help to explain why young, healthy adults – who normally find it easier to shake off flu – were the worst affected, since in this case their stronger immune systems created an even more severe cytokine storm."
BBC, Why the Flu of 1918 Was So Deadly
"Seneca had made the bargain that many good men have made when agreeing to aid bad regimes. Their presence strengthens the regime and helps it endure. But their moral influence may also improve the regime's behavior. For many, this has been a bargain worth making, even if it has cost them—as it may have cost Seneca—their immortal soul. The Rome he has been trained to serve, the Rome of Augustus and Germanicus, was gone. In its place stood Neropolis, ruled by a megalomaniac brat.” James Romm